Journal article
Persistence of Rare Salmonella Typhi Genotypes Susceptible to First-Line Antibiotics in the Remote Islands of Samoa
MJ Sikorski, TH Hazen, SN Desai, S Nimarota-Brown, S Tupua, M Sialeipata, S Rambocus, DJ Ingle, S Duchene, SA Ballard, M Valcanis, S Zufan, J Ma, JW Sahl, M Maes, G Dougan, RE Thomsen, RM Robins-Browne, BP Howden, TK Naseri Show all
Mbio | AMER SOC MICROBIOLOGY | Published : 2022
Abstract
For decades, the remote island nation of Samoa (population;200,000) has faced endemic typhoid fever despite improvements in water quality, sanitation, and economic development. We recently described the epidemiology of typhoid fever in Samoa from 2008 to 2019 by person, place, and time; however, the local Salmonella enterica serovar Typhi (S. Typhi) population structure, evolutionary origins, and genomic features remained unknown. Herein, we report whole genome sequence analyses of 306 S. Typhi isolates from Samoa collected between 1983 and 2020. Phylogenetics revealed a dominant population of rare genotypes 3.5.4 and 3.5.3, together comprising 292/306 (95.4%) of Samoan versus 2/4934 (0.04%)..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by the Bill & Melinda Gates Foundation OPP1194582 (INV000049) (PI: Myron M. Levine). Under the grant conditions of the Foundation, a Creative Commons Attribution 4.0 Generic License has already been assigned to the Author Accepted Manuscript version that might arise from this submission. M.J.S. received research support in part by federal funds fromNational Institutes of Health under National Institute of Allergy and Infectious Diseases grants F30AI156973 (PI: Michael J. Sikorski) and U19AI110820 (PI: David A. Rasko), as well as National Institute of Diabetes and Digestive and Kidney Diseases training grant T32DK067872 (PI: Jean-Pierre Raufman). M.M.L. is supported in part by the Simon and Bessie Grollman Distinguished Professorship at the University of Maryland School of Medicine. The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of themanuscript; and decision to submit themanuscript for publication.