Journal article
Transcriptomic profiling of cardiac tissues from SARS-CoV-2 patients identifies DNA damage
A Kulasinghe, N Liu, CW Tan, J Monkman, JE Sinclair, DD Bhuva, D Godbolt, L Pan, A Nam, H Sadeghirad, K Sato, GL Bassi, K O'Byrne, C Hartmann, AFR dos Santos Miggiolaro, GL Marques, LZ Moura, D Richard, M Adams, L de Noronha Show all
Immunology | Published : 2023
DOI: 10.1111/imm.13577
Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to present with pulmonary and extra-pulmonary organ complications. In comparison with the 2009 pandemic (pH1N1), SARS-CoV-2 infection is likely to lead to more severe disease, with multi-organ effects, including cardiovascular disease. SARS-CoV-2 has been associated with acute and long-term cardiovascular disease, but the molecular changes that govern this remain unknown. In this study, we investigated the host transcriptome landscape of cardiac tissues collected at rapid autopsy from seven SARS-CoV-2, two pH1N1, and six control patients using targeted spatial transcriptomics approaches. Although SARS-CoV-2 was not det..
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Awarded by Australian Acoustical Society
Funding Acknowledgements
Australian Academy of Sciences; NHMRC, Grant/Award Numbers: 1157741, 2007919, 1135898, 2008542; The Prince Charles Hospital Foundation (The Common Good)