Journal article
Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes
T Glauser, E Ben-Menachem, B Bourgeois, A Cnaan, C Guerreiro, R Kälviäinen, R Mattson, JA French, E Perucca, T Tomson
Epilepsia | WILEY | Published : 2013
DOI: 10.1111/epi.12074
Abstract
Summary The purpose of this report was to update the 2006 International League Against Epilepsy (ILAE) report and identify the level of evidence for long-term efficacy or effectiveness for antiepileptic drugs (AEDs) as initial monotherapy for patients with newly diagnosed or untreated epilepsy. All applicable articles from July 2005 until March 2012 were identified, evaluated, and combined with the previous analysis (Glauser et al., 2006) to provide a comprehensive update. The prior analysis methodology was utilized with three modifications: (1) the detectable noninferiority boundary approach was dropped and both failed superiority studies and prespecified noninferiority studies were analyze..
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Funding Acknowledgements
Dr Glauser has received grants and research support from the National Institutes of Health, Abbott, GlaxoSmithKline, and Pfizer; consultation/advisory boards/speaking honoraria from Eisai, Upsher-Smith, Sunovion, Supernus, Ortho-McNeil Pharmaceutical, Ovation, Questcor, and UCB Pharmaceutical; and royalties from AssureRx. Dr Ben-Menachem served during the past year on a scientific board for Eisai and UCB and Lundbeck Inc. (formerly Ovation Pharmaceuticals, Inc.). She serves on a speaker's bureau for Eisai, Janssen-Cilag, UCB, and receives research support from Johnson & Johnson, UCB, and Eisai Inc. Dr Bourgeois has received grants and research support from Eisai, Ovation, and UCB Pharma; and consultation and advisory board honorarium from Genzyme and Beyer Material Science. Dr Cnaan serves as a member of an International Data Monitoring Committee for GlaxoSmithKline. Dr Guerreiro has received grants and research support from Abbott, GlaxoSmithKline, Jansen-Cilag, Novartis, and Bial; consultation, speaking honoraria and advisory board honorarium from Abbott, GlaxoSmithKline, Jansen-Cilag, Novartis, Merck-Serono, and Lundbeck. Dr Kalviainen has received grants and research support from Neurosearch, Novartis, Pfizer, Schwarz Pharma; UCB Pharma, Sanofi-Aventis, and GlaxoSmithKline; and consultation/advisory boards/speaking honoraria from Cephalon, GlaxoSmithKline, UCB Pharma, Janssen Cilag, Pfizer, Johnson & Johnson, Novartis, and Sanofi-Aventis. Dr Mattson has received grants and research support from IVAX; and consultation/advisory boards/speaking honoraria from Abbott, Bertek, Elan, Eisai, GlaxoSmithKline, Novartis, Ortho-McNeil Pharmaceutical, Pfizer, Shire, and UCB Pharma. Dr French has served on scientific advisory boards for UCB, Johnson & Johnson, Eisai Inc., Novartis, Valeant Pharmaceuticals International, Icagen, Inc., Intranasal Therapeutics Inc., Sepracor Inc., and Marinus Pharmaceuticals, Inc.; has received funding for travel from UCB, Kyowa Hakko Kirin Pharma, Inc., Eisai Inc., Johnson & Johnson, Valeant Pharmaceuticals International, and GlaxoSmithKline; serves as an Associate Editor for Epilepsy Currents and the supplements editor for Epileptic Disorders; is president of the Epilepsy Study Consortium, which receives money from multiple pharmaceutical companies; 25% of her salary is paid to NYU by the consortium; and she has received research support from SK Pharma Co., Ltd., Valeant Pharmaceuticals International, Pfizer Inc, UCB, Eisai, Johnson & Johnson, the NIH, and the Epilepsy Research Foundation. Dr Perucca has received speaker's or consultancy fees and/or research grants from Bial, Eisai, GlaxoSmithKline, Johnson and Johnson, Novartis, Pfizer, Sanofi Aventis, Sunovion, SK Life Science, Supernus, UCB Pharma, and Valeant, Prof Tomson serves as an Associate Editor for Epilepsia and on the editorial boards of Epilepsy Research and Epileptic Disorders; has received funding for travel and speaker honoraria from UCB; and receives research support from Eisai Inc., GlaxoSmithKline, Johnson & Johnson/Janssen, Novartis, sanofi-aventis, Pfizer Inc, UCB, ALF (Stockholm County Council), and CURE. We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.