A distinct intra-individual suppression subnetwork in the brain's default mode network across cognitive tasks

Christine A Leonards; Ben J Harrison; Alec J Jamieson; Trevor Steward; Silke Lux; Alexandra Philipsen; Christopher G Davey

Journal article

A distinct intra-individual suppression subnetwork in the brain's default mode network across cognitive tasks

Christine A Leonards, Ben J Harrison, Alec J Jamieson, Trevor Steward, Silke Lux, Alexandra Philipsen, Christopher G Davey

CEREBRAL CORTEX | OXFORD UNIV PRESS INC | Published : 2023

DOI: 10.1093/cercor/bhac361

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Abstract

Suppression of the brain’s default mode network (DMN) during external goal-directed cognitive tasks has been consistently observed in neuroimaging studies. However, emerging insights suggest the DMN is not a monolithic “task-negative” network but is comprised of subsystems that show functional heterogeneity. Despite considerable research interest, no study has investigated the consistency of DMN activity suppression across multiple cognitive tasks within the same individuals. In this study, 85 healthy 15- to 25-year-olds completed three functional magnetic resonance imaging tasks that were designed to reliably map DMN suppression from a resting baseline. Our findings revealed a distinct supp..

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University of Melbourne Researchers

Ben Harrison Author

Alec Jamieson Author

Trevor Steward Author

Chris Davey Author

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)

Awarded by NHMRC Career Development Fellowship

Funding Acknowledgements

This work was supported by National Health and Medical Research Council of Australia (NHMRC) Project Grants (grant number 1024570 to CGD and 1064643 to BJH). CGD was supported by an NHMRC Career Development Fellowship (grant number 1061757). BJH was supported by an NHMRC Career Development Fellowship (grant number1124472). CAL and AJJ were supported by an Australian Government Research Training Program Scholarship.