Journal article
Maternal gut microbiota during pregnancy and the composition of immune cells in infancy
Y Gao, M O’Hely, TP Quinn, AL Ponsonby, LC Harrison, H Frøkiær, MLK Tang, S Brix, K Kristiansen, D Burgner, R Saffery, S Ranganathan, F Collier, P Vuillermin
Frontiers in Immunology | FRONTIERS MEDIA SA | Published : 2022
Open access
Abstract
Background: Preclinical studies have shown that maternal gut microbiota during pregnancy play a key role in prenatal immune development but the relevance of these findings to humans is unknown. The aim of this prebirth cohort study was to investigate the association between the maternal gut microbiota in pregnancy and the composition of the infant’s cord and peripheral blood immune cells over the first year of life. Methods: The Barwon Infant Study cohort (n=1074 infants) was recruited using an unselected sampling frame. Maternal fecal samples were collected at 36 weeks of pregnancy and flow cytometry was conducted on cord/peripheral blood collected at birth, 6 and 12 months of age. Among a ..
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Awarded by Murdoch Children's Research Institute
Funding Acknowledgements
This study was funded by the National Health and Medical Research Council of Australia (1082307, 1147980), the Australian Food Allergy Foundation, The Murdoch Children's Research Institute, Barwon Health and Deakin University.