Journal article
The effects of B-cell–activating factor on the population size, maturation and function of murine natural killer cells
PS Quah, V Sutton, E Whitlock, WA Figgett, DM Andrews, KA Fairfax, F Mackay
Immunology and Cell Biology | Published : 2022
DOI: 10.1111/imcb.12585
Open access
Abstract
The role of B-cell–activating factor (BAFF) in B-lymphocyte biology has been comprehensively studied, but its contributions to innate immunity remain unclear. Natural killer (NK) cells form the first line of defense against viruses and tumors, and have been shown to be defective in patients with systemic lupus erythematosus (SLE). The link between BAFF and NK cells in the development and progression of SLE remains unstudied. By assessing NK cell numbers in wild-type (WT), BAFF−/− (BAFF deficient), BAFF-R−/− (BAFF receptor deficient), TACI−/− (transmembrane activator and calcium modulator and cyclophilin ligand interactor deficient), BCMA−/− (B-cell maturation antigen deficient) and BAFF tran..
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Awarded by Lupus Research Alliance
Funding Acknowledgements
We acknowledge the Alfred Medical Research and Education Precinct Flow Cytometry Facility and the Melbourne Cytometry Platform (Doherty Institute Node) for flow cytometry services and assistance with cell sorting. We thank Antonio Garci ' a (bio-graphics) for his assistance with the graphical abstract. Pin Shie Quah was supported by the Monash University Postgraduate Research Scholarship and the Faculty of Medicine International Postgraduate Scholarship. Kirsten A Fairfax is a recipient of the Alex Gadomski Fellowship, which is funded by Maddie Riewoldt's Vision. Fabienne Mackay was supported by the National Health and Medical Research Council of Australia (NHMRC; GNT11443687) and Lupus Research Alliance USA. Open access publishing facilitated by The University of Melbourne, as part of the Wiley -The University of Melbourne agreement via the Council of Australian University Librarians.