The role of mucosal-associated invariant T cells in visceral leishmaniasis

MDL Moreira; LO Borges-Fernandes; MA Pascoal-Xavier; ÁL Ribeiro; VHS Pereira; T Pediongco; MSDS Araújo; A Teixeira-Carvalho; AL de Carvalho; MVA Mourão; FA Campos; M Borges; M Carneiro; Z Chen; E Saunders; M McConville; M Tsuji; J McCluskey; OA Martins-Filho; SBG Eckle; JGA Coelho-dos-Reis; V Peruhype-Magalhães

Journal article

The role of mucosal-associated invariant T cells in visceral leishmaniasis

MDL Moreira, LO Borges-Fernandes, MA Pascoal-Xavier, ÁL Ribeiro, VHS Pereira, T Pediongco, MSDS Araújo, A Teixeira-Carvalho, AL de Carvalho, MVA Mourão, FA Campos, M Borges, M Carneiro, Z Chen, E Saunders, M McConville, M Tsuji, J McCluskey, OA Martins-Filho, SBG Eckle Show all

Frontiers in Immunology | Published : 2022

DOI: 10.3389/fimmu.2022.926446

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Abstract

Mucosal-associated invariant T (MAIT) cells are restricted by MR1 and are known to protect against bacterial and viral infections. Our understanding of the role of MAIT cells in parasitic infections, such as visceral leishmaniasis (VL) caused by protozoan parasites of Leishmania donovani, is limited. This study showed that in response to L. infantum, human peripheral blood MAIT cells from children with leishmaniasis produced TNF and IFN-γ in an MR1-dependent manner. The overall frequency of MAIT cells was inversely correlated with alanine aminotransferase levels, a specific marker of liver damage strongly associated with severe hepatic involvement in VL. In addition, there was a positive cor..

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University of Melbourne Researchers

Marcela De Lima Moreira Author

Zhenjun Chen Author

Eleanor Saunders Author

Malcolm McConville Author

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Awarded by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Funding Acknowledgements

JC-d-R received financial support from the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico -MCTI/CNPq/2014 - Grant# 458134/2014-7) and a fellowship from the Brazilian National Postdoctoral Fellowship Program (PNPD/CAPES). VP-M received financial support from the Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG - Grant# APQ-01754-14 and PPM-00497-16). This study was financed in parts by the Coordenacao de Aperfeicoamento de Pessoal de-Nivel Superior -Brasil (CAPES) - Finance Code 001. SE was supported by a fellowship from the Australian Research Council (ARC) (ARC DECRA DE170100407) and a fellowship and project grant from the Australian National Health and Medical Research Council (NHMRC fellowship APP1196881 and project grant GNT1157388). JC-d-R (Pq2), OM-F (Pq1B), AT-C (Pq1D), MC (Pq1D), and MSA (Pq2) thank CNPq for their Senior Research Productivity Fellowships. MT received financial support from the National Institutes of Health (R01-AI070258).