Journal article
The SCRIPT trial: study protocol for a randomised controlled trial of a polygenic risk score to tailor colorectal cancer screening in primary care
S Saya, L Boyd, P Chondros, M McNamara, M King, S Milton, RDA Lourenco, M Clark, G Fishman, J Marker, C Ostroff, R Allman, FM Walter, D Buchanan, I Winship, J McIntosh, F Macrae, M Jenkins, J Emery
Trials | Published : 2022
Abstract
Background: Polygenic risk scores (PRSs) can predict the risk of colorectal cancer (CRC) and target screening more precisely than current guidelines using age and family history alone. Primary care, as a far-reaching point of healthcare and routine provider of cancer screening and risk information, may be an ideal location for their widespread implementation. Methods: This trial aims to determine whether the SCRIPT intervention results in more risk-appropriate CRC screening after 12 months in individuals attending general practice, compared with standard cancer risk reduction information. The SCRIPT intervention consists of a CRC PRS, tailored risk-specific screening recommendations and a ri..
View full abstractRelated Projects (1)
Grants
Awarded by Cancer Research UK
Funding Acknowledgements
This study is funded by a dedicated research grant from Cancer Australia (APP1183338). The funder does not have input or ultimate authority in the study design; collection, management, analysis and interpretation of data; the writing of the report; and the decision to submit the report for publication.