Journal article
Quantitative lung ultrasound detects dynamic changes in lung recruitment in the preterm lamb
A Sett, GWC Foo, KR Kenna, RJ Sutton, EJ Perkins, M Sourial, SR Rogerson, BJ Manley, PG Davis, PM Pereira-Fantini, DG Tingay
Pediatric Research | Published : 2023
Open access
Abstract
Background: Lung ultrasound (LUS) may not detect small, dynamic changes in lung volume. Mean greyscale measurement using computer-assisted image analysis (Q-LUSMGV) may improve the precision of these measurements. Methods: Preterm lambs (n = 40) underwent LUS of the dependent or non-dependent lung during static pressure–volume curve mapping. Total and regional lung volumes were determined using the super-syringe technique and electrical impedance tomography. Q-LUSMGV and gold standard measurements of lung volume were compared in 520 images. Results: Dependent Q-LUSMGV moderately correlated with total lung volume (rho = 0.60, 95% CI 0.51–0.67) and fairly with right whole (rho = 0.39, 0.27–0.4..
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Awarded by Australasian Society for Ultrasound in Medicine
Funding Acknowledgements
This study is supported by the Victorian Government Operational Infrastructure Support Program (Melbourne, Australia) and a grant from the National Health and Medical Research Council (NHMRC; Grant ID 1182676). A.S. is supported by a research grant from the Australasian Society of Ultrasound in Medicine, a PhD scholarship from the Centre of Research Excellence in Newborn Medicine, Melbourne and a Research Training Program PhD fee-offset scholarship from the Victorian Government. D.G.T. is supported by a Royal Children's Hospital Foundation Clinical Scientist Fellowship and NHMRC Investigator (Grant ID 2008212). P.G.D. is supported by an NHMRC Practitioner Fellowship (Grant ID 556600). B.J.M. is supported by a Medical Research Future Fund (Australia) Fellowship Grant (Grant ID 1159225). GE Healthcare provided the Logiq E ultrasound system but was not involved in the study design, analysis, or interpretation of results. Open Access funding enabled and organized by CAUL and its Member Institutions.