Journal article
Cortical thinning 3 years after ischaemic stroke is associated with cognitive impairment and APOE ε4
M Salah Khlif, N Egorova-Brumley, LJ Bird, E Werden, A Brodtmann
Neuroimage Clinical | Published : 2022
Abstract
Cortical thinning has been described in many neurodegenerative diseases and used for both diagnosis and disease monitoring. The imaging signatures of post-stroke vascular cognitive impairment have not been well described. We investigated the trajectory of cortical thickness over 3 years following ischaemic stroke compared to healthy stroke-free age- and sex-matched controls. We also compared cortical thickness between cognitively normal and impaired stroke survivors, and between APOE ɛ4 carriers and non-carriers. T1-weighted MRI and cognitive data for 90 stroke survivors and 36 controls from the Cognition And Neocortical Volume After Stroke (CANVAS) study were used. Cortical thickness was es..
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Funding Acknowledgements
The Florey Institute of Neuroscience and Mental Health acknowledges the support from the Victorian Government (Operational Infrastructure Support Grant) and the support from the HPC system operated by Research Platform Services at University of Melbourne. The authors acknowledge the facilities, scientific and technical assistance of the National Imaging Facility at the Florey. This work was supported by National Health and Medical Research Council (NHMRC) grant (APP1020526) , Brain Foundation, Wicking Trust, Collie Trust, and Sidney and Fiona Myer Family Foundation. NEB was supported by Australian Research Council (ARC) grant (DE180100893) . AB was supported by National Heart Foundation Future Leader Fellowships (100784 and 104748) .