Journal article
Galectin-7 dysregulates renin-angiotensin-aldosterone and NADPH oxide synthase pathways in preeclampsia
E Menkhorst, W Zhou, L Santos, JG Zhang, Y St-Pierre, MJ Young, E Dimitriadis
Pregnancy Hypertension | ELSEVIER SCI LTD | Published : 2022
Abstract
Objectives: Preeclampsia is a life-threatening disorder of pregnancy unique to humans. Poor placentation in the first trimester of pregnancy is widely accepted to be an underlying cause of preeclampsia. Galectin-7 is abnormally elevated in chorionic villous samples and serum from women that subsequently develop pre-term preeclampsia. Administration of exogenous galectin-7 to pregnant mice causes preeclampsia-like features (hypertension, proteinuria), associated with dysregulation of the renin-angiotensin system (RAS). In this study investigated the mechanism by which galectin-7 induces alterations to tissue RAS homeostasis and ROS production. We hypothesized that galectin-7 induces alteratio..
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Grants
Awarded by NHMRC (Australia)
Funding Acknowledgements
This work was supported by the NHMRC (Australia) Project/Program Grant (GNT1098332) and Fellowship (#550905 to ED), the University of Melbourne Department of Obstetrics and Gynecology Midcareer Fellowship to EM, the Trevor Basil Kilvington Bequest and the Victorian Government's Operational Infrastructure Support. The funders were not involved in the conduct of research, preparation of the manuscript or the decision to publish. The authors have no competing financial interests.