Journal article
Does repeated influenza vaccination attenuate effectiveness? A systematic review and meta-analysis
E Jones-Gray, EJ Robinson, AJ Kucharski, A Fox, SG Sullivan
Lancet Respiratory Medicine | ELSEVIER SCI LTD | Published : 2023
Open access
Abstract
Background: Influenza vaccines require annual readministration; however, several reports have suggested that repeated vaccination might attenuate the vaccine's effectiveness. We aimed to estimate the reduction in vaccine effectiveness associated with repeated influenza vaccination. Methods: In this systematic review and meta-analysis, we searched MEDLINE, EMBASE, and CINAHL Complete databases for articles published from Jan 1, 2016, to June 13, 2022, and Web of Science for studies published from database inception to June 13, 2022. For studies published before Jan 1, 2016, we consulted published systematic reviews. Two reviewers (EJ-G and EJR) independently screened, extracted data using a d..
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Awarded by National Institutes of Health
Funding Acknowledgements
This systematic review and meta-analysis was commissioned and partly supported by WHO for the Strategic Advisory Group of Experts (SAGE) on Immunization. EJR and EJ-G were additionally supported by US National Institutes of Health project grant (R01AI141534) . The authors are responsible for the views expressed in this article and they do not necessarily represent the decisions, policy, or views of WHO or the US National Institutes of Health. We thank Stephany Sanchez (Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia) for assistance with Spanish language articles; Xin (Kelly) Mu (University of Melbourne, Melbourne, VIC, Australia) for assistance with Chinese language articles; Arseniy Khvorov (Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia) for assistance with Russian language articles; Kylie Ainslie (National Institute for Public Health and the Environment, Bilthoven, Netherlands) for assistance with Dutch language articles; Yuzo Arima (National Institute for Infectious Diseases, Tokyo, Japan) and Miku Kuba (Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia) for assistance with Japanese language articles. We also thank members of the SAGE Immunization Working Group on Influenza for feedback on the original report. The WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health and Aged Care.