Journal article
ATH434 Rescues Pre-motor Hyposmia in a Mouse Model of Parkinsonism
LC Beauchamp, XM Liu, LJ Vella, PA Adlard, AI Bush, DI Finkelstein, KJ Barnham
Neurotherapeutics | ELSEVIER SCIENCE INC | Published : 2022
Abstract
Hyposmia is a prevalent prodromal feature of Parkinson’s disease (PD), though the neuropathology that underlies this symptom is poorly understood. Unlike the substantia nigra, the status of metal homeostasis in the olfactory bulbs has not been characterized in PD. Given the increasing interest in metal modulation as a therapeutic avenue in PD, we sought to investigate bulbar metals and the effect of AT434 (formerly PBT434) an orally bioavailable, small molecule modulator of metal homeostasis on hyposmia in a mouse model of parkinsonism (the tau knockout (tau−/−) mouse). 5.5 (pre-hyposmia) and 13.5-month-old (pre-motor) mice were dosed with ATH434 (30 mg/kg/day, oral gavage) for 6 weeks. Anim..
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Funding Acknowledgements
Open Access funding enabled and organized by CAUL and its Member Institutions. LCB was supported by an Australian Training Research Scholarship. AIB and KJB were supported by funding from the National Health & Medical Research Council of Australia. Additional support was from the Victorian government's Operational Infrastructure Support Program.