Journal article
Co-infection of the four major Plasmodium species: Effects on densities and gametocyte carriage
A Holzschuh, M Gruenberg, NE Hofmann, R Wampfler, B Kiniboro, LJ Robinson, I Mueller, I Felger, MT White
Plos Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2022
Abstract
Background Co-infection of the four major species of human malaria parasite Plasmodium falciparum (Pf), P. vivax (Pv), P. malariae (Pm), and P. ovale sp. (Po) is regularly observed, but there is limited understanding of between-species interactions. In particular, little is known about the effects of multiple Plasmodium species co-infections on gametocyte production. Methods We developed molecular assays for detecting asexual and gametocyte stages of Pf, Pv, Pm, and Po. This is the first description of molecular diagnostics for Pm and Po gameto-cytes. These assays were implemented in a unique epidemiological setting in Papua New Guinea with sympatric transmission of all four Plasmodium speci..
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Awarded by Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Funding Acknowledgements
This work was carried out with funding awarded to IF from the Swiss National Science Foundation (grants no. 310030-134889 and 310030-159580), NIH NIAID International Centres of Excellence in Malaria Research South West Pacific (U19 AI089686) and Asia Pacific (U19 AI129392-01) awarded to IM. Field work was supported by the TransEPI consortium funded by the Bill & Melinda Gates Foundation awarded to IM. IM (GNT11155075) and LJR (GNT1161627) are supported by NHMRC Fellowships. MTW is supported by the French Government's Laboratoire d'Excellence "Integrative Biology of Emerging Infectious Diseases" (Investissement d'Avenir grant no ANR-10-LABX-62-IBEID), and the INCEPTION program (Investissement d'Avenir grant ANR-16CONV-0005). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.