Journal article
Cerebrospinal fluid neurofilament light chain differentiates behavioural variant frontotemporal dementia progressors from non-progressors
D Eratne, M Keem, C Lewis, M Kang, M Walterfang, S Farrand, S Loi, W Kelso, C Cadwallader, SF Berkovic, QX Li, CL Masters, S Collins, A Santillo, D Velakoulis
Journal of the Neurological Sciences | ELSEVIER | Published : 2022
Abstract
Background: Distinguishing behavioural variant frontotemporal dementia (bvFTD) from non-neurodegenerative ‘non-progressor’ mimics of frontal lobe dysfunction, can be one of the most challenging clinical dilemmas. A biomarker of neuronal injury, neurofilament light chain (NfL), could reduce misdiagnosis and delay. Methods: Cerebrospinal fluid (CSF) NfL, amyloid beta 1–42 (AB42), total and phosphorylated tau (T-tau, P-tau) levels were examined in patients with an initial diagnosis of bvFTD. Based on follow-up information, patients were categorised as Progressors or Non-Progressors: further subtyped into Non-Progressor Revised (non-neurological/neurodegenerative final diagnosis), and Non-Progre..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
We are grateful for funding that supported this work: the Trisno Family Research Grant in Old Age Psychiatry, three NorthWestern Mental Health Research Seed Grants, MACH MRFF RART 2.1, and NHMRC (1185180). Finally, the authors would like to thank all the patients and their families for their participation. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication.