Journal article
The establishment of a cytomegalovirus -specific CD8 T-cell threshold by kinetic modeling for the prediction of post-hemopoietic stem cell transplant reactivation
J Zhang, J Cao, R Zheng, M Yu, Z Lin, C Wang, J McCluskey, J Yang, Z Chen, AJ Corbett, P Cao, W Mo, Z Wang
Iscience | CELL PRESS | Published : 2022
Open access
Abstract
The dynamic interaction between the CMV virus and host immune response remains obscure, thus hindering the diagnosis and therapeutic management of patients with HSCT. The current diagnosis of CMV viremia depends on viral load estimation. Medical intervention based on viral load, can be unnecessary or poorly timed for many patients. Here we examined the clinical features and blood samples of patients with HSCT and assessed the CMV reactivation kinetics and corresponding CMV antigen-specific T-cell response in individual patients based on a peptide pool stimulation T-cell assay, which showed that CMV-specific CD8+ T cells were more suitable to be a diagnosis indicator for suppressing CMV react..
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Awarded by National Natural Science Foundation of China
Funding Acknowledgements
This work was supported by China Postdoctoral Science Foundation (2019M662863); Guangdong Basic and Applied Basic Research Foundation (2019A1515110782); Guangdong Province General Colleges and Universities Youth Innovative Talents Project (2019KQNCX120); State Key Lab of Respiratory Disease Independent Project (SKLRD-Z-202003); The grants of Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Disease (GHMJLRID-Z-202119); The grants from National Key Basic Research Project (2019YFC0810900); Ministry of Science and Technology of P.R. China (2021YFC0864400), and NSFC (81971485); Guangdong Key Basic Research Project (2019B1515120068); Guangdong Key Research and Development Project (2020B1111330001); Emergency Key Program of Guangzhou Laboratory (No. EKPG21-30-1).