In Vivo 7-Tesla MRI Investigation of Brain Iron and Its Metabolic Correlates in Chronic Schizophrenia

P Ravanfar; WT Syeda; M Jayaram; RJ Rushmore; B Moffat; AP Lin; AE Lyall; AH Merritt; N Yaghmaie; L Laskaris; S Luza; CM Opazo; B Liberg; MM Chakravarty; GA Devenyi; P Desmond; VL Cropley; N Makris; ME Shenton; AI Bush; D Velakoulis; C Pantelis

Journal article

In Vivo 7-Tesla MRI Investigation of Brain Iron and Its Metabolic Correlates in Chronic Schizophrenia

P Ravanfar, WT Syeda, M Jayaram, RJ Rushmore, B Moffat, AP Lin, AE Lyall, AH Merritt, N Yaghmaie, L Laskaris, S Luza, CM Opazo, B Liberg, MM Chakravarty, GA Devenyi, P Desmond, VL Cropley, N Makris, ME Shenton, AI Bush Show all

Schizophrenia | NATURE PORTFOLIO | Published : 2022

DOI: 10.1038/s41537-022-00293-1

Download PDF

Abstract

Brain iron is central to dopaminergic neurotransmission, a key component in schizophrenia pathology. Iron can also generate oxidative stress, which is one proposed mechanism for gray matter volume reduction in schizophrenia. The role of brain iron in schizophrenia and its potential link to oxidative stress has not been previously examined. In this study, we used 7-Tesla MRI quantitative susceptibility mapping (QSM), magnetic resonance spectroscopy (MRS), and structural T1 imaging in 12 individuals with chronic schizophrenia and 14 healthy age-matched controls. In schizophrenia, there were higher QSM values in bilateral putamen and higher concentrations of phosphocreatine and lactate in cauda..

View full abstract

University of Melbourne Researchers

Warda Syeda Author

Mahesh Jayaram Author

Bradford Moffat Author

Toni Merritt Author

Related Projects (1)

TRANSLATING MEMBRANE PROTEINS INTO THERAPEUTICS; FROM BEDSIDE TO BENCH

Grants

Awarded by University of Melbourne

Funding Acknowledgements

V.L.C. is supported by a National Health and Medical Research Council (NHMRC) Investigator Grant (1177370) and a University of Melbourne Dame Kate Campbell Fellowship. N.M. is supported by NIH grants: R01MH125860, R01MH112748, R01MH111917, K24MH116366, R01AG042512, R21DA042271. A.I.B. is supported by an NHMRC L3 Investigator Grant (1194028) and by the generous donation of Mr Douglas Stutt to the University of Melbourne. C.P. is supported by NHMRC L3 Investigator Grant (1196508). The study was supported by a Royal Melbourne Hospital Grant in Aid (GIA-030H2016) to C.P., V.L.C., B.M., P.D.), and NHMRC Program Grant to C.P. (ID: 1150083). A.E.L. is supported by NIH grants NIMH 1 K01 MH115247-01A1 and 1K24MH110807-01A1, a Brain and Behavior Research Foundation Young Investigator Award and a Brigham and Women's Department of Psychiatry Internal Funding Award. R.J.R. is supported by NIMH grant R01MH112748. M.E.S. is supported by NIH grant 5 U01MH109977. The authors acknowledge the facilities and scientific and technical assistance of the National Imaging Facility, a National Collaborative Research Infrastructure Strategy (NCRIS) capability, at the Melbourne Brain Centre Imaging Unit, University of Melbourne, Victoria Australia. Authors acknowledge the statistical analysis support received from Mr. Peter Summers at Melbourne Statistical Consulting Platform, The University of Melbourne. This research was enabled in part by support provided by Compute Canada (www.computecanada.ca).This work was supported in part by the MASSIVE HPC facility (www.massive.org.au).The authors thank Enterprise Research Infrastructure & Services (ERIS) at Partners HealthCare for their in-depth support.