Journal article
Changes in the Syphilis Rapid Plasma Reagin Titer Between Diagnosis and Treatment
Katrina Pandey, Christopher K Fairley, Marcus Y Chen, Deborah A Williamson, Catriona S Bradshaw, Jason J Ong, Ei T Aung, Eric PF Chow
CLINICAL INFECTIOUS DISEASES | OXFORD UNIV PRESS INC | Published : 2023
DOI: 10.1093/cid/ciac843
Open access
Abstract
Background. We compared the rapid plasma reagin (RPR) titer on the day of initial presentation with that on the day of syphilis treatment to inform clinical practice as to whether a repeated RPR test should be recommended. Methods. We undertook a retrospective study between 1 March 2011 and 31 December 2020 at the Melbourne Sexual Health Centre in Australia among individuals who underwent syphilis serology on the day of initial presentation and the day of treatment, if the latter were within 14 days after initial presentation. We calculated the percentage of individuals with a ≥4-fold change in RPR titer, stratified by the time between initial presentation and treatment and by syphilis stage..
View full abstractGrants
Awarded by Australian NationalHealth and Medical Research Council (NHMRC)
Funding Acknowledgements
This work was supported by the Australian NationalHealth and Medical Research Council (NHMRC; GNT1174555 toD. A. W., GNT1193955 to J. J. O, and GNT1172873 to E. P. F. C. and GNT1172900 to C. K. F. and GNT1173361 to C. S. B.); MonashUniversity (Research Training Program scholarship to E. T. A.); and the Chapter of Sexual Health Medicine, Royal Australasian College ofPhysicians (research entry scholarship to E. T. A.).