Journal article
Ectonucleoside triphosphate diphosphohydrolase-1 (CD39) impacts TGF-β1 responses: insights into cardiac fibrosis and function following myocardial infarction
T Novitskaya, S Nishat, R Covarrubias, DG Wheeler, E Chepurko, O Bermeo-Blanco, Z Xu, B Baer, H He, SN Moore, KM Dwyer, PJ Cowan, YR Su, TS Absi, J Schoenecker, LM Bellan, WJ Koch, S Bansal, I Feoktistov, SC Robson Show all
American Journal of Physiology Heart and Circulatory Physiology | Published : 2022
Abstract
Extracellular purine nucleotides and nucleosides released from activated or injured cells influence multiple aspects of cardiac physiology and pathophysiology. Ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1; CD39) hydrolyzes released nucleotides and thereby regulates the magnitude and duration of purinergic signaling. However, the impact of CD39 activity on post-myocardial infarction (MI) remodeling is incompletely understood. We measured the levels and activity of ectonucleotidases in human left ventricular samples from control and ischemic cardiomyopathy (ICM) hearts and examined the impact of ablation of Cd39 expression on post-myocardial infarction remodeling in mice. We found ..
View full abstractGrants
Awarded by National Heart, Lung, and Blood Institute
Funding Acknowledgements
This work was supported in part by National Institutes of Health (NIH) Training Grant 5T32HL007411-35 (to R.C.) and NIH Grants P01 HL091799 (to W.J.K.); P01 HL107152, P01 HL087203, and R01DK103723 (to S.C.R.); and R01-HL127442-A1, R21-HL096038, and K08-HL094703 (to R.J.G.) and the Robert J. Anthony Fund for Cardiovascular Research (to R.J.G.).