Journal article
Head and neck cancer N-glycome traits are cell line and HPV status–dependent
M Rasheduzzaman, AVM Murugan, X Zhang, T Oliveira, R Dolcetti, L Kenny, NW Johnson, D Kolarich, C Punyadeera
Analytical and Bioanalytical Chemistry | SPRINGER HEIDELBERG | Published : 2022
Open access
Abstract
Glycosylation is the most common post-translational modification of proteins, and glycosylation changes at cell surfaces are frequently associated with malignant epithelia including head and neck squamous cell carcinoma (HNSCC). In HNSCC, 5-year survival remains poor, averaging around 50% globally: this is partly related to late diagnosis. Specific protein glycosylation signatures on malignant keratinocytes have promise as diagnostic and prognostic biomarkers and as therapeutic targets. Nevertheless, HNSCC-specific glycome is to date largely unknown. Herein, we tested six established HNSCC cell lines to capture the qualitative and semi-quantitative N-glycome using porous graphitized carbon l..
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Awarded by Australian Government
Funding Acknowledgements
Chamindie Punyadeera is currently receiving funding from Cancer Australia (APP1145657), National Health and Medical Research Council (APP 2002576) and Medical Research Future Fund (MRFF) Rapid Applied Research Translation Program (Centre for Personalised Analysis of Cancers and RBWH Foundation). Daniel Kolarich (DK) is the recipient of an Australian Research Council Future Fellowship (project number FT160100344) funded by the Australian Government. This research is also supported by an Australian Government grant by project CE140100003 and by a Research Training Program (RTP) Scholarship to Mohammad Rasheduzzaman (MR).