Journal article
Umbilical Cord Blood Cell Clearance Post-Infusion in Immune-Competent Children with Cerebral Palsy
K Crompton, DE Godler, L Ling, N Elwood, F Mechinaud-Heloury, T Soosay Raj, KC Hsiao, J Fleming, K Tiedemann, I Novak, M Fahey, X Wang, KJ Lee, PB Colditz, P Edwards, D Reddihough
Cells Tissues Organs | KARGER | Published : 2023
DOI: 10.1159/000527612
Abstract
Umbilical cord blood cells have therapeutic potential for neurological disorders, through a paracrine mechanism of action. A greater understanding of the safety and immunological effects of allogeneic donor cord blood cells in the context of a healthy recipient immune system, such as in cerebral palsy, is needed. This study aimed to determine how quickly donor cord blood cells were cleared from the circulation in children with cerebral palsy who received a single intravenous infusion of 12/12 human leucocyte antigen (HLA)-matched sibling cord blood cells. Twelve participants with cerebral palsy aged 2-12 years received cord blood cell infusions as part of a phase I trial of umbilical blood i..
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Awarded by Cerebral Palsy Alliance Research Foundation
Funding Acknowledgements
This work was generously supported by Cell Care Australia Pty Ltd and the Cerebral Palsy Alliance Research Foundation. DEG was funded by a Career Development Fellowship, from the Medical Research Future Fund (MRF1141334).