Journal article
Phylodynamic signatures in the emergence of community-associated MRSA
E Steinig, I Aglua, S Duchene, MT Meehan, M Yoannes, C Firth, J Jaworski, J Drekore, B Urakoko, H Poka, C Wurr, E Ebos, D Nangen, E Müller, P Mulvey, C Jackson, A Blomfeldt, HV Aamot, M Laman, L Manning Show all
Proceedings of the National Academy of Sciences of the United States of America | Published : 2022
Abstract
Community-associated, methicillin-resistant Staphylococcus aureus (MRSA) lineages have emerged in many geographically distinct regions around the world during the past 30 y. Here, we apply consistent phylodynamic methods across multiple community-associated MRSA lineages to describe and contrast their patterns of emergence and dissemination. We generated whole-genome sequencing data for the Australian sequence type (ST) ST93-MRSA-IV from remote communities in Far North Queensland and Papua New Guinea, and the Bengal Bay ST772-MRSA-V clone from metropolitan communities in Pakistan. Increases in the effective reproduction number (Re) and sustained transmission (Re > 1) coincided with spread of..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
E.S. was supported by a Policy relevant infectious disease simulation and mathematical modelling (PRISM2) & Improving Health Outcomes in the Tropical North (HOT North) pilot grant (Australian National Health and Medical Research Council [NHMRC] ID 1131932). C.F. is supported by a HOT North fellowship (NHMRC ID 1131932). S.Y.C.T. is supported by an Australian NHMRC fellowship (ID 1145033). GPU models were run on the Linkage Infrastructure, Equipment and Facilities (LIEF) HPC-GPGPU Facility hosted at the University of Melbourne (LIEF grant LE170100200).