Journal article
Thrombectomy Outcomes With General vs Nongeneral Anesthesia: A Pooled Patient-Level Analysis From the EXTEND-IA Trials and SELECT Study
A Sarraj, GW Albers, PJ Mitchell, AE Hassan, MG Abraham, S Blackburn, G Sharma, N Yassi, TJ Kleinig, DG Shah, TY Wu, MS Hussain, WG Tekle, SO Gutierrez, AN Aghaebrahim, DC Haussen, G Toth, D Pujara, RF Budzik, W Hicks Show all
Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2023
Abstract
Background and Objectives: The effect of anesthesia choice on endovascular thrombectomy (EVT) outcomes is unclear. Collateral status on perfusion imaging may help identify the optimal anesthesia choice. Methods: In a pooled patient-level analysis of EXTEND-IA, EXTEND-IA TNK, EXTEND-IA TNK part II, and SELECT, EVT functional outcomes (modified Rankin Scale score distribution) were compared between general anesthesia (GA) vs non-GA in a propensity-matched sample. Furthermore, we evaluated the association of collateral flow on perfusion imaging, assessed by hypoperfusion intensity ratio (HIR) - Tmax > 10 seconds/Tmax > 6 seconds (good collaterals - HIR < 0.4, poor collaterals - HIR ≥ 0.4) on th..
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Funding Acknowledgements
The SELECT trial was funded by Stryker Neurovascular through a grant to UT McGovern Medical School. EXTEND-IA trials were funded by the National Health and Medical Research Council of Australia. The pooled analysis efforts received no funding. The funding source was not involved in study design, monitoring, data collection, statistical analyses, interpretation of results, or manuscript writing