Journal article
IL7RA single nucleotide polymorphisms are associated with the size and function of the MAIT cell population in treated HIV-1 infection
F Han, MY Gulam, Y Zheng, NS Zulhaimi, WR Sia, D He, A Ho, L Hadadi, Z Liu, P Qin, PE Lobie, A Kamarulzaman, LF Wang, JK Sandberg, SR Lewin, R Rajasuriar, E Leeansyah
Frontiers in Immunology | Published : 2022
Abstract
MAIT cells are persistently depleted and functionally exhausted in HIV-1-infected patients despite long-term combination antiretroviral therapy (cART). IL-7 treatment supports MAIT cell reconstitution in vivo HIV-1-infected individuals and rescues their functionality in vitro. Single-nucleotide polymorphisms (SNPs) of the IL-7RA gene modulate the levels of soluble(s)IL-7Rα (sCD127) levels and influence bioavailability of circulating IL-7. Here we evaluate the potential influence of IL-7RA polymorphisms on MAIT cell numbers and function in healthy control (HC) subjects and HIV-1-infected individuals on long-term cART. Our findings indicate that IL-7RA haplotype 2 (H2*T), defined as T-allele c..
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Awarded by H2020 Marie Skłodowska-Curie Actions
Funding Acknowledgements
The research was supported by grants from Swedish Research Council Grant 2015-00174, Marie Sklodowska Curie Actions, Cofund, Project INCA 600398, the Jonas Soederquist Foundation for Virology and Immunology, the Petrus and Augusta Hedlund Foundation, Tsinghua Shenzhen International Graduate School Research Startup Funds (No. 01030100004), and the Shenzhen Pengcheng Peacock Program (to EL). The establishment of the clinical cohort and genotyping was supported by the High Impact Research grant (HIR/MOHE; H-20001-E000001) to RR, SL, and AK.