Journal article
Default Mode Network Modulation by Psychedelics: A Systematic Review
James J Gattuso, Daniel Perkins, Simon Ruffell, Andrew J Lawrence, Daniel Hoyer, Laura H Jacobson, Christopher Timmermann, David Castle, Susan L Rossell, Luke A Downey, Broc A Pagni, Nicole L Galvao-Coelho, David Nutt, Jerome Sarris
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | OXFORD UNIV PRESS | Published : 2023
DOI: 10.1093/ijnp/pyac074
Open access
Abstract
Psychedelics are a unique class of drug that commonly produce vivid hallucinations as well as profound psychological and mystical experiences. A grouping of interconnected brain regions characterized by increased temporal coherence at rest have been termed the Default Mode Network (DMN). The DMN has been the focus of numerous studies assessing its role in self-referencing, mind wandering, and autobiographical memories. Altered connectivity in the DMN has been associated with a range of neuropsychiatric conditions such as depression, anxiety, post-traumatic stress disorder, attention deficit hyperactive disorder, schizophrenia, and obsessive-compulsive disorder. To date, several studies have ..
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Awarded by Senior National Health and Medical Research Council (NHMRC) Fellowship
Funding Acknowledgements
Acknowledgments No direct funding was provided for the writing of this article. Susan Rossell is supported by a Senior National Health and Medical Research Council (NHMRC) Fellowship (GNT1154651). We acknowledge support from the Victorian State Government Operational Infrastructure Scheme.