Dendritic Mechanisms for In Vivo Neural Computations and Behavior

L Fischer; RM Soto-Albors; VD Tang; B Bicknell; C Grienberger; V Francioni; R Naud; LM Palmer; N Takahashi

Journal article

Dendritic Mechanisms for In Vivo Neural Computations and Behavior

L Fischer, RM Soto-Albors, VD Tang, B Bicknell, C Grienberger, V Francioni, R Naud, LM Palmer, N Takahashi

Journal of Neuroscience | SOC NEUROSCIENCE | Published : 2022

DOI: 10.1523/JNEUROSCI.1132-22.2022

Abstract

Dendrites receive the vast majority of a single neuron’s inputs, and coordinate the transformation of these signals into neuronal output. Ex vivo and theoretical evidence has shown that dendrites possess powerful processing capabilities, yet little is known about how these mechanisms are engaged in the intact brain or how they influence circuit dynamics. New experimental and computational technologies have led to a surge in interest to unravel and harness their computational potential. This review highlights recent and emerging work that combines established and cutting-edge technologies to identify the role of dendrites in brain function. We discuss active dendritic mediation of sensory per..

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University of Melbourne Researchers

Lucy Palmer Author

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Grants

Awarded by Université de Bordeaux

Funding Acknowledgements

L.F. was supported by National Institutes of Health Grant R01NS106031. R.M.S.-A. and V.D.T. were supported by the Department of Brain and Cognitive Sciences at Massachusetts Institute of Technology. N.T. was supported by University of Bordeaux (Initiative of Excellence), Region Nouvelle-Aquitaine and Centre National de la Recherche Scientifique/Institut National de la Sante et de la Recherche Medicale ATIP-Avenir program. B.B. was supported by European Union Grant MSCA-IF 845956. L.M.P. was supported by NHMRC APP1086082 and APP1063533, Australian Research Council DP160103047, and Sylvia and Charles Viertel Charitable Foundation. C.G. was supported by the Smith Family Awards Program for Excellence in Biomedical Research and Air Force Office of Scientific Research Award FA9550-22-1-0344. We thank Mark T. Harnett and members of the Harnett laboratory for feedback on this manuscript.