1030 – THE REGULATION OF HEMATOPOIESIS BY VITAMIN A: A TUG OF WAR.

Abstract

We make billions of mature blood cells every day through highly defined processes involving the commitment and differentiation of hematopoietic stem cells (HSCs). The regulation of HSCs occurs both intrinsically and extrinsically, the latter via specialised bone marrow (BM) microenvironments. It has been recognised for over 50 years that BM microenvironments play important roles in regulating blood cell production. Despite this, it has only been in the last two decades that the contribution of BM microenvironments in regulating hematopoiesis has become an area of widespread interest in the field. Our research has previously shown that the biologically active form of vitamin A, all-trans reti..