Journal article
The RTS,S malaria vaccine: Current impact and foundation for the future
JG Beeson, L Kurtovic, C Valim, KP Asante, MJ Boyle, D Mathanga, C Dobano, G Moncunill
Science Translational Medicine | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2022
Abstract
The RTS,S vaccine has recently been recommended for implementation as a childhood vaccine in regions with moderate-to-high malaria transmission. We discuss mechanisms of vaccine protection and longevity, implementation considerations, and future research needed to increase the vaccine’s health impact, including vaccine modifications for higher efficacy and longevity of protection.
Grants
Awarded by Spanish Ministry of Science and Innovation through the Centro de Excelencia Severo Ochoa 2019-2023 Program
Funding Acknowledgements
J.G.B., L.K., and M.J.B. are supported by the National Health and Medical Research Council Australia (Investigator Grant to J.G.B., Career Development Fellowship to M.J.B., and Australian Centre for Research Excellence in Malaria Elimination). ISGlobal acknowledges support from the Spanish Ministry of Science and Innovation through the Centro de Excelencia Severo Ochoa 2019-2023 Program (CEX2018-000806-S) and support from the Generalitat de Catalunya through the CERCA Program. Malaria vaccine research is part of the ISGlobal's Program on the Molecular mechanisms of malaria, which is partially supported by the Fundacion Ramon Areces. Burnet Institute is supported by an NHMRC Independent Research Institutes Infrastructure Support Scheme and a Victorian Government Operational Infrastructure Support grant.