Leukocyte surface biomarkers implicate deficits of innate immunity in sporadic Alzheimer's disease

X Huang; Y Li; C Fowler; JD Doecke; YY Lim; C Drysdale; V Zhang; K Park; B Trounson; K Pertile; R Rumble; JW Pickering; RA Rissman; F Sarsoza; S Abdel-Latif; Y Lin; V Doré; V Villemagne; CC Rowe; J Fripp; R Martins; JS Wiley; P Maruff; JE Mintzer; CL Masters; BJ Gu

Journal article

Leukocyte surface biomarkers implicate deficits of innate immunity in sporadic Alzheimer's disease

X Huang, Y Li, C Fowler, JD Doecke, YY Lim, C Drysdale, V Zhang, K Park, B Trounson, K Pertile, R Rumble, JW Pickering, RA Rissman, F Sarsoza, S Abdel-Latif, Y Lin, V Doré, V Villemagne, CC Rowe, J Fripp Show all

Alzheimer S and Dementia | WILEY | Published : 2023

DOI: 10.1002/alz.12813

Abstract

Introduction: Blood-based diagnostics and prognostics in sporadic Alzheimer's disease (AD) are important for identifying at-risk individuals for therapeutic interventions. Methods: In three stages, a total of 34 leukocyte antigens were examined by flow cytometry immunophenotyping. Data were analyzed by logistic regression and receiver operating characteristic (ROC) analyses. Results: We identified leukocyte markers differentially expressed in the patients with AD. Pathway analysis revealed a complex network involving upregulation of complement inhibition and downregulation of cargo receptor activity and Aβ clearance. A proposed panel including four leukocyte markers – CD11c, CD59, CD91, and ..

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University of Melbourne Researchers

Victor Villemagne Author

Christopher Rowe Author

Paul Maruff Author

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Grants

Awarded by National Institutes of Health

Funding Acknowledgements

ARC Future Fellowship, Grant/Award Number: FT120100581; NHMRC, Grant/Award Numbers: 1048082, 1061419, 1120095, 110178; Ministry of Science and Technology of China, Grant/Award Number: SQ2018YFC200022; Bethlehem Griffiths Research Foundation, Grant/Award Number: BGRF1901; Victorian Government's Operational Infrastructure; Florey Institute; NIA; NIH, Grant/Award Numbers: AG058252, AG073979, AG051848