Journal article
Higher Doses of FSH Used for Superovulation Do Not Adversely Affect Embryonic Ploidy: A Randomised Controlled Trial (Stimulation Resulting in Embryonic Aneuploidy Using Menopur (STREAM) Trial)
Akshara SHYAMSUNDER, Tristan HARDY, Anusch YAZDANI, Alex POLYAKOV, Robert NORMAN, Roger HART, Franca AGRESTA, Luk ROMBAUTS, Clare BOOTHROYD, Michael CHAPMAN, Prudence SWEETEN, Eleanor SOMERVILLE, Rachel JOSE, Handan WAND, William L LEDGER
Fertility & Reproduction | World Scientific Pub Co Pte Ltd | Published : 2022
Abstract
Background: High dose gonadotropin stimulation protocols may increase costs, patient discomfort, likelihood of ovarian hyper stimulation syndrome (OHSS), ovarian torsion and increased bleeding after multiple ovarian punctures. In addition, it is possible that high dose stimulation may result in impaired oocyte “quality” with adverse effect of embryonic ploidy. This may negate any benefits seen from a higher oocyte yield after high dose stimulation. Aim: To determine the proportion of euploid blastocysts resulting from higher versus lower dose ovarian stimulation protocols. Method: Multicentre randomised controlled trial recruiting 57 women who were treated with ovarian stimulation using ei..
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