Journal article
Novel plasma and brain proteins that are implicated in multiple sclerosis
X Lin, Y Yang, M Gresle, G Cuellar-Partida, X Han, J Stankovich, S Simpson-Yap, V Fuh-Ngwa, J Charlesworth, KP Burdon, H Butzkueven, BV Taylor, Y Zhou
Brain | OXFORD UNIV PRESS | Published : 2023
Abstract
Understanding how variations in the plasma and brain proteome contribute to multiple sclerosis susceptibility can provide important insights to guide drug repurposing and therapeutic development for the disease. However, the role of genetically predicted protein abundance in multiple sclerosis remains largely unknown. Integrating plasma proteomics (n= 3301) and brain proteomics (n=376 discovery; n=152 replication) into multiple sclerosis genome-wide association studies (n= 14 802 cases and 26 703 controls), we employed summary-based methods to identify candidate proteins involved in multiple sclerosis susceptibility. Next, we evaluated associations of the corresponding genes with multiple sc..
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Awarded by Mater Foundation
Funding Acknowledgements
Acknowledgements We thank the research volunteers whose gifts make this work possible, as well as the investigators who have made their datasets freely available to undertake research of this type. We would also like to acknowledge the use of the high-performance computing facilities provided by Digital Research at the University of Tasmania.