Journal article
Longitudinal IgG antibody responses to Plasmodium vivax blood-stage antigens during and after acute vivax malaria in individuals living in the Brazilian Amazon
T Tashi, A Upadhye, P Kundu, C Wu, S Menant, RR Soares, MU Ferreira, RJ Longley, I Mueller, QQ Hoang, WH Tham, JC Rayner, KKG Scopel, JC Lima-Junior, TM Tran
Plos Neglected Tropical Diseases | Published : 2022
Abstract
Background To make progress towards malaria elimination, a highly effective vaccine targeting Plasmo-dium vivax is urgently needed. Evaluating the kinetics of natural antibody responses to vaccine candidate antigens after acute vivax malaria can inform the design of serological markers of exposure and vaccines. Methodology/Principal findings The responses of IgG antibodies to 9 P. vivax vaccine candidate antigens were evaluated in longitudinal serum samples from Brazilian individuals collected at the time of acute vivax malaria and 30, 60, and 180 days afterwards. Antigen-specific IgG correlations, seropreva-lence, and half-lives were determined for each antigen using the longitudinal data. ..
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Grants
Awarded by National Institutes of Health
Funding Acknowledgements
This project was funded with support from the Indiana Clinical and Translational Sciences Institute funded, in part by Grant Number UL1TR002529 from the National Institutes of Health (NIH), National Center for Advancing Translational Sciences, Clinical and Translational Sciences Award. T.M.T was supported by NIHK 08AI125682. Additional support was provided by NIH R01 AI137154 (J.C.R). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. W.H.T. is a Howard Hughes Medical InstituteWellcome Trust International Research Scholar (208693/Z/17/Z) and supported by National Health and Medical Research Council of Australia (NHMRC) (GNT1160042, GNT1154937). R.J.L. and I.M. are also supported by the NHMRC (GNT1173210 to R.J.L., GNT1092789, GNT1134989, GNT1132975 and GNT1043345 to I. M.). The original field study was supported by Fundacao de Amparo a Pesquisa de Minas Gerais (FAPEMIG, APQ-00769-12) and Conselho Nacional de Desenvolvimento Cienti ' fico e Tecnolo ' gico (CNPq: 470315/2012-1). R.N.R.S. and M.U.F. were recipients of CAPES doctoral and CNPq senior research fellowships, respectively. Q.Q.H. acknowledges funding from the NIH (R01GM111639, R01GM115844) and the Michael J. Fox Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.