Journal article
A soft and ultrasensitive force sensing diaphragm for probing cardiac organoids instantaneously and wirelessly
Q Lyu, S Gong, JG Lees, J Yin, LW Yap, AM Kong, Q Shi, R Fu, Q Zhu, A Dyer, JM Dyson, SY Lim, W Cheng
Nature Communications | NATURE PORTFOLIO | Published : 2022
Abstract
Time-lapse mechanical properties of stem cell derived cardiac organoids are important biological cues for understanding contraction dynamics of human heart tissues, cardiovascular functions and diseases. However, it remains difficult to directly, instantaneously and accurately characterize such mechanical properties in real-time and in situ because cardiac organoids are topologically complex, three-dimensional soft tissues suspended in biological media, which creates a mismatch in mechanics and topology with state-of-the-art force sensors that are typically rigid, planar and bulky. Here, we present a soft resistive force-sensing diaphragm based on ultrasensitive resistive nanocracked platinu..
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Awarded by Jack Brockhoff Foundation
Funding Acknowledgements
This research was financially supported under Discovery Projects funding scheme (DP200100624), NHMRC Investigator Grant Leadership Fellow (APP2010154) and Jack Brockhoff foundation (JBF Grant number 4659-2019). This work was performed in part at the Melbourne Centre for Nanofabrication (MCN) in the Victorian Node of the Australian National Fabrication Facility (ANFF). This work was performed with support from the St Vincent's Hospital (Melbourne) Research Endowment Fund and Stafford Fox Medical Research Foundation. The O'Brien Institute Department of St Vincent's Institute of Medical Research receives Operational Infrastructure Support from the yVictorian State Government's Department of Innovation, Industry and Regional Development.