Journal article
Comparison of antibody responses to SARS-CoV-2 variants in Australian children
ZQ Toh, N Mazarakis, J Nguyen, RA Higgins, J Anderson, LAH Do, DP Burgner, N Curtis, AC Steer, K Mulholland, NW Crawford, S Tosif, PV Licciardi
Nature Communications | NATURE PORTFOLIO | Published : 2022
Abstract
There is limited understanding of antibody responses in children across different SARS-CoV-2 variants. As part of an ongoing household cohort study, we assessed the antibody response among unvaccinated children infected with Wuhan, Delta, or Omicron variants, as well as vaccinated children with breakthrough Omicron infection, using a SARS-CoV-2 S1-specific IgG assay and surrogate virus neutralization test (% inhibition). Most children infected with Delta (100%, 35/35) or Omicron (81.3%, 13/16) variants seroconverted by one month following infection. In contrast, 37.5% (21/56) children infected with Wuhan seroconverted, as previously reported. However, Omicron-infected children (geometric mea..
View full abstractGrants
Awarded by National Institutes of Health
Funding Acknowledgements
We thank the study participants and families for their involvement in this study. We also acknowledge the SAEFVIC Research Team (Alissa McMinn, Hayley Giuliano, Kate Hession, Belle Overmars, Chelsea Bartel). We also acknowledge the Murdoch Children's Research Institute (MCRI) Biobanking service for their help in processing the samples. Funding for the recruitment of participants was provided by the Royal Children's Hospital Foundation and the MCRI Infection and Immunity Theme, grants from the DHB Foundation and the Victorian Department of Jobs, Precincts, and Regions. This work is supported by Victorian Government's Medical Research Operational Infrastructure Support Programme. MCRI. P.V.L. is supported by NHMRC Career Development Fellowship. D.B., A.C.S., and N.C. are supported by NHMRC Investigator Grants. A.C.S. is supported by a Viertel Senior Medical Research Fellowship. S.T. is supported by a MCRI Clinician Scientist Fellowship. Z.Q.T. is supported by an MCRI Early Career Fellowship.