Intestinal microbe-derived metabolites instruct macrophages in the lungs

A Roquilly; JA Villadangos

Journal article

Intestinal microbe-derived metabolites instruct macrophages in the lungs

A Roquilly, JA Villadangos

Nature Immunology | NATURE PORTFOLIO | Published : 2022

DOI: 10.1038/s41590-022-01358-0

Abstract

The bacillus Calmette–Guérin (BCG) vaccine induces homotypic protection against tuberculosis and, surprisingly, heterotypic protection against other pathogens. New work shows that BCG vaccination causes leakage of microbial gut metabolites into circulation, which induces changes in alveolar macrophages protective against pneumonia.

University of Melbourne Researchers

Jose Villadangos Author

Related Projects (1)

FUNCTIONAL IMPAIRMENT OF MOUSE AND HUMAN DENDRITIC CELLS FOLLOWING SYSTEMIC INFLAMMATORY RESPONSE SYNDROME (SIRS): TOWARDS NOVEL DIAGNOSTICS AND TREATMENTS

Severe infections, trauma or stroke cause Systemic Inflammatory Response Syndrome (SIRS). SIRS patients often succumb to otherwise innocuous..

Grants

Awarded by Horizon 2020

Funding Acknowledgements

A.R. isa recipient of European Union's Horizon 2020 research and innovation program grant 847782 and receives funds from the Agence National dela Recherche (ANR) JCJC for the PROGR-AM project. J.A.V. is funded by a National Health and Medical Research Council (NHMRC) of Australia Fellowship (1154502). A.R. and J.A.V. are recipients of NHMRC Project Grant 1163090.