Journal article
Acquisition of antibodies to Plasmodium falciparum and Plasmodium vivax antigens in pregnant women living in a low malaria transmission area of Brazil
MW Kassa, W Hasang, A Barateiro, T Damelang, J Brewster, JG Dombrowski, RJ Longley, AW Chung, G Wunderlich, I Mueller, EH Aitken, CRF Marinho, SJ Rogerson
Malaria Journal | BMC | Published : 2022
Abstract
Background: Pregnant women have increased susceptibility to Plasmodium falciparum malaria and acquire protective antibodies over successive pregnancies. Most studies that investigated malaria antibody responses in pregnant women are from high transmission areas in sub-Saharan Africa, while reports from Latin America are scarce and inconsistent. The present study sought to explore the development of antibodies against P. falciparum and Plasmodium vivax antigens in pregnant women living in a low transmission area in the Brazilian Amazon. Methods: In a prospective cohort study, plasma samples from 408 pregnant women (of whom 111 were infected with P. falciparum, 96 had infections with P. falcip..
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Grants
Awarded by University of Melbourne
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council of Australia (NHMRC; Program Grant GNT1092789, Project Grant GNT1143946 to SJR and the Australian Centre for Research Excellence in Malaria Elimination GNT1134989), a grant from the University of Melbourne-FAPESP SPRINT program to SJR, and grants from Sao Paulo Research Foundation - FAPESP (grants 2017/50181-2 and 2018/20468-0); and The National Council for Scientific and Technological Development -CNPq (grant 302917/2019-5 and 408636/2018-1) to CRFM. JGD and AB were supported by fellowships from FAPESP (2019/12068-5 and 2017/03939-7, respectively).