Journal article
A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health
N Fernandez-Jimenez, R Fore, A Cilleros-Portet, J Lepeule, P Perron, T Kvist, FY Tian, C Lesseur, AM Binder, M Lozano, J Martorell-Marugán, YJ Loke, KM Bakulski, Y Zhu, A Forhan, S Sammallahti, TM Everson, J Chen, KB Michels, T Belmonte Show all
Communications Biology | Published : 2022
Abstract
Higher maternal pre-pregnancy body mass index (ppBMI) is associated with increased neonatal morbidity, as well as with pregnancy complications and metabolic outcomes in offspring later in life. The placenta is a key organ in fetal development and has been proposed to act as a mediator between the mother and different health outcomes in children. The overall aim of the present work is to investigate the association of ppBMI with epigenome-wide placental DNA methylation (DNAm) in 10 studies from the PACE consortium, amounting to 2631 mother-child pairs. We identify 27 CpG sites at which we observe placental DNAm variations of up to 2.0% per 10 ppBMI-unit. The CpGs that are differentially methy..
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Awarded by National Institute of Environmental Health Sciences
Funding Acknowledgements
We would like to thank the Pregnancy and Childhood Epigenetics (PACE) consortium, as well as all the families that participated in these studies for their generous contribution. This work was partially funded by GVSAN2018111086 from the Basque Department of Health and PI18/01142 from ISCIII -Spanish Ministry of Science and Innovation cofounded by the ERDF "A way to make Europe" to JRB and LSM, respectively; and by the Joint Programming Initiative -A Healthy Diet for a Healthy Life (JPI HDHL) (NutriPROGRAM). ACP was supported by grant GVSAN2019111085 from the Basque Department of Health to NFJ. Detailed acknowledgements and funding for each participating cohort are described in Supplementary Note 1.