Excellent treatment outcomes from low dose radiation therapy for primary cutaneous CD4 small/medium T-Cell lymphoproliferative disorder

Abstract

Background and Purpose: Primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder (PCSMLPD) is a benign behaving condition, typically manifesting as solitary head or neck papules, frequently creating cosmetic concerns. Optimal management of this rare disease is unclear. Herein, patterns of care and treatment outcomes are described, with particular focus on low-dose RT. Materials and Methods: Eligibility required biopsy-proven PCSMLPD on central review, diagnosed between 2007–2022. Patterns of care, treatment responses and relapse patterns were assessed. Freedom-from-progression (FFP) was compared between RT and surgery. Results: 41 patients were eligible. First-line treatments..