Chemistry and Biology of Acyloin Natural Products

Abstract

This review details the isolation, biosynthesis, biological activity,and synthesis of ?-hydroxy ketone (acyloin) natural products. Therole of these compounds as biosynthetic precursors to complex naturalproducts and synthetic strategies to access the sensitive acyloin moietyand stereochemistry are highlighted.1 Introduction1.1 Xenocyloins1.2 Biological Activity1.3 Biosynthesis1.4 Acyloins as Discoipyrrole Biosynthetic Precursors2 Total Synthesis of Acyloin Natural Products2.1 Kurasoins A and B2.2 Soraphinol A and Circumcin B2.3 4-Hydroxysattabacin and Actinopolymorphol A2.4 Actinopolymorphol B2.5 Sattazolins and Sattabacins2.6 Catalyst Development and Application in Acyloin Synthesis2.7 Xeno..