Progressive resistance training in young people with Prader-Willi syndrome: Protocol for a randomised trial (PRESTO)

Abstract

Introduction Preliminary evidence suggests that progressive resistance training may be beneficial for people with Prader-Willi Syndrome (PWS), a rare genetic condition that results in muscle weakness and low muscle tone.To establish whether community-based progressive resistance training is effective in improving the muscle strength of people with PWS; to determine cost-effectiveness; and, to complete a process evaluation assessing intervention fidelity, exploring mechanisms of impact, understanding participant experiences and identifying contextual factors affecting implementation. Methods and analysis A multisite, randomised controlled trial will be completed. Sixty participants with PWS w..