Journal article
Insomnia symptoms and markers of preclinical Alzheimer’s disease in the community
Jessica Nicolazzo, Marina G Cavuoto, Madeline Gibson, Ella Rowsthorn, Rachel F Buckley, Nawaf Yassi, Stephanie Yiallourou, Amy Brodtmann, Garun S Hamilton, Matthew T Naughton, Yen Ying Lim, Matthew P Pase
Alzheimer's & Dementia | Wiley | Published : 2022
DOI: 10.1002/alz.067324
Abstract
AbstractBackgroundAmyloid production increases during wakefulness before being cleared during sleep. Insomnia is one of the commonest sleep disorders, yet its relationship to core markers of preclinical Alzheimer’s disease remains unknown. We investigated the cross‐sectional relationship between insomnia symptom severity, APOE e4 carriage, and cerebrospinal spinal fluid (CSF) concentrations of Alzheimer’s disease biomarkers in a non‐demented community‐sample aged 43‐67 years.Method66 participants from the Healthy Brain Project Biomarker Sub‐study (age = 58±6 years; MMSE = 29±7; 68% women) completed a lumbar puncture, two weeks of actigraphy to measure sleep and wake patterns, and the Insomni..
View full abstract