Journal article
Cerebrovascular injury markers explain the effect of systemic vascular risk on cognitive decline in older adults with lower amyloid burden
Zahra Shirzadi, Wai‐Ying Wendy Yau, Jennifer S Rabin, Rachel F Buckley, Michael J Properzi, Jessie Fanglu Fu, Stephanie Hsieh, Emma G Thibault, Parisa Mojiri‐Forooshani, Maged Goubran, Bradley J MacIntosh, Sandra E Black, Julie C Price, Keith A Johnson, Reisa A Sperling, Jasmeer P Chhatwal, Aaron P Schultz
Alzheimer's & Dementia | Wiley | Published : 2022
DOI: 10.1002/alz.066686
Abstract
AbstractBackgroundSystemic vascular risk is a well‐established contributor to late‐life cognitive decline, yet the mechanism is not completely understood. We investigated whether neuroimaging‐based measures of vascular injury (white matter hyperintensity (WMH) volume, Peak width of Skeletonized Mean Diffusivity (PSMD), and relative cerebral blood flow (rCBF)) could explain the effect of systemic vascular risk on cognitive decline using longitudinal data from the Harvard Aging Brain Study.MethodWe used the Framingham Heart Study cardiovascular disease risk score (FHS‐CVD) as an index of systemic vascular risk. We extracted WMH from structural MRI (https://hypermapp3r.readthedocs.io/) and PSMD..
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