Journal article
Longitudinal hippocampal atrophy is associated with cognitive decline independently of amyloid and tau in neocortex
Bernard Hanseeuw, Heidi IL Jacobs, Aaron P Schultz, Rachel F Buckley, Michael J Properzi, Alex Becker, Michelle E Farrell, Justin S Sanchez, Kathryn V Papp, Hyun‐Sik Yang, Jasmeer P Chhatwal, Julie C Price, Georges El Fakhri, Dorene M Rentz, Reisa A Sperling, Keith A Johnson
Alzheimer's & Dementia | Wiley | Published : 2022
DOI: 10.1002/alz.069271
Abstract
AbstractBackgroundHippocampal volume (HV) atrophy is a well‐known biomarker of cognitive impairment. However, it is not specific for Alzheimer’s disease (AD). To disentangle the contributions of AD and other neuropathologies to cognitive decline, we investigated the longitudinal associations between HV and cognition, adjusting for Aβ and tau in participants from the Harvard Aging Brain Study who were clinically normal (CN) at inclusion.MethodsSerial MRI (HV [1.3‐7.0y], PiB‐PET (Aβ, [1.9‐8.5y]), Flortaucipir‐PET (tau, [0.8‐6.0y]), and the Preclinical Alzheimer Cognitive Composite (PACC, [3.0‐8.8y]) were observed over an average five‐year follow‐up in 128 CN participants, including ten who pro..
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