CSF biomarkers for Alzheimer Disease are associated with spatial cognition in cognitively normal older adults

Abstract

AbstractBackgroundSpatial cognition has emerged as a promising cognitive fingerprint for the detection of Alzheimer’s disease (AD). Despite evidence that spatial cognition is highly sensitive to AD dementia and is apparent even in adults at‐genetic‐risk of AD, the association between spatial cognition and AD biomarkers in cognitively normal adults is unknown.MethodThis study leverages data from the European Prevention of Alzheimer’s Dementia Consortium, a multinational observational study of clinically normal adults initiated in 2016 that includes two digital spatial paradigms: The Supermarket Task (SMT)and the Four Mountains Task (4MT;Fig1). Using a mixed model approach with random intercep..