Journal article
Insomnia Symptoms and Biomarkers of Alzheimer's Disease in the Community
J Nicolazzo, M Cavuoto, E Rowsthorn, L Cribb, L Bransby, M Gibson, P Wall, D Velakoulis, D Eratne, R Buckley, N Yassi, S Yiallourou, A Brodtmann, GS Hamilton, MT Naughton, YY Lim, MP Pase
Journal of Alzheimer S Disease | IOS PRESS | Published : 2023
DOI: 10.3233/JAD-220924
Abstract
Background: Insomnia is one of the most common sleep disorders yet its relationship to the biology of Alzheimer's disease remains equivocal. Objective: We investigated the cross-sectional relationship between insomnia symptom severity and cerebrospinal fluid (CSF) concentrations of Alzheimer's disease biomarkers in a cognitively unimpaired middle-aged community sample. Methods: A total of 63 participants from the Healthy Brain Project (age=59±7 years; 67% women) completed a lumbar puncture and two weeks of actigraphy to measure two of insomnia's core features: difficulty initiating sleep (prolonged sleep onset latency) and difficulty maintaining sleep (wake after sleep onset [WASO] and numbe..
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Awarded by National Institutes of Health
Funding Acknowledgements
Dr. Pase is supported by a National Heart Foundation of Australia Future Leader Fellowship (GTN102052) with sleep and dementia research funding from the National Health and Medical Research Council of Australia (GTN2009264; GTN1158384), National Institute on Aging (R01 AG062531-01A1), and Alzheimer's Association (2018-AARG-591358). Dr Cavuoto and Dr Pase are supported by a Dementia Australia Research Foundation award (Lucas' Papaw Remedies Project Grant). The Healthy Brain Project (healthy-brainproject.org.au) is funded by the National Health and Medical Research Council (NHMRC; GNT1158384, GNT1147465, GNT1111603, GNT1105576, GNT1104273, GNT1171816), the Alzheimer's Association (AARG-17-591424, AARG-18-591358, AARG-19-643133), the Dementia Australia Research Foundation, the Yulgilbar Alzheimer's Research Program, and the Charleston Conference for Alzheimer's Disease. Dr Lim is supported by an NHMRC Career Development Fellowship (GNT1162645), and an NHMRC Emerging Leadership Grant (GNT2009550). Dr Buckley is supported by a National Institutes of Health K99R00 award (K99AG061238) and an Alzheimer's Association Research Fellowship. Ms. Bransby is supported by a Dementia Australia Research Foundation PhD scholarship.