Journal article
A Spiky Silver-Iron Oxide Nanoparticle for Highly Efficient Targeted Photothermal Therapy and Multimodal Imaging of Thrombosis
KX Vazquez-Prada, SS Moonshi, Y Wu, F Akther, BWC Tse, KA Sokolowski, K Peter, X Wang, G Xu, HT Ta
Small | WILEY-V C H VERLAG GMBH | Published : 2023
Open access
Abstract
Thrombosis and its complications are responsible for 30% of annual deaths. Limitations of methods for diagnosing and treating thrombosis highlight the need for improvements. Agents that provide simultaneous diagnostic and therapeutic activities (theranostics) are paramount for an accurate diagnosis and rapid treatment. In this study, silver-iron oxide nanoparticles (AgIONPs) are developed for highly efficient targeted photothermal therapy and imaging of thrombosis. Small iron oxide nanoparticles are employed as seeding agents for the generation of a new class of spiky silver nanoparticles with strong absorbance in the near-infrared range. The AgIONPs are biofunctionalized with binding ligand..
View full abstractGrants
Awarded by Australian National Fabrication Facility
Funding Acknowledgements
This work was funded by National Health and Medical Research Council (HTT: APP1037310, APP1182347, and APP2002827). K.V.P. was supported by a PhD scholarship from the University of Queensland. H.T.T. was supported by a Heart Foundation Future Leader Fellowship (102761). K.P. was supported by a NHMRC Investigator Fellowship. X.W. was supported by a National Heart Foundation Future Leader Fellowship and a Baker Fellowship. The authors would like to acknowledge the Australian National Fabrication Facility (Queensland Node) access to key items of equipment. The authors acknowledge the facilities and scientific and technical assistance of the National Imaging Facility, a National Collaborative Research Infrastructure Strategy (NCRIS) capability, at the Centre for Advanced Imaging, University of Queensland. The authors thank Dr. Craig Stoppiello from the Centre for Microscopy and Microanalysis (The University of Queensland) for his help with XPS analysis. Open access publishing facilitated by Griffith University, as part of the Wiley - Griffith University agreement via the Council of Australian University Librarians.