Journal article
Effectiveness of Intranasal Mometasone Furoate vs Saline for Sleep-Disordered Breathing in Children: A Randomized Clinical Trial
A Baker, A Grobler, K Davies, A Griffiths, H Hiscock, H Kubba, RL Peters, S Ranganathan, J Rimmer, E Rose, K Rowe, CM Simpson, A Davidson, G Nixon, KP Perrett
JAMA Pediatrics | Published : 2023
Abstract
Importance: Obstructive sleep-disordered breathing (SDB) in children is characterized by snoring and difficulty breathing during sleep. SDB affects at least 12% of otherwise healthy children and is associated with significant morbidity. Evidence from small clinical trials suggests that intranasal corticosteroids improve SDB as measured by polysomnography; however, the effect on symptoms and quality of life is unclear. Objective: To determine whether intranasal mometasone furoate is more effective than intranasal saline for improving symptoms and quality of life in children with SDB. Design, Setting, and Participants: The MIST trial was a multicenter, randomized, double-blind, placebo-control..
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Funding Acknowledgements
The trial was funded by research grants from The Passe and Williams Foundation,Murdoch Children's Research Institute, the Royal Children's Hospital Foundation, and the MonashHealth Foundation awarded to Drs Perrett, Nixon,and Baker.