Journal article
Individualized vancomycin dosing in infants: prospective evaluation of an online dose calculator
AL Wilkins, T Lai, X Zhu, S Bolisetty, R Chiletti, N Cranswick, K Gardiner, R Hunt, A Malhotra, B McMullan, B Mehta, J Michalowski, H Popat, M Ward, S Duffull, N Curtis, A Gwee
International Journal of Antimicrobial Agents | Published : 2023
Abstract
Background: Empiric vancomycin dosing regimens fail to achieve recommended target trough concentrations of 10-20 mg/L in the majority of infants. This study assessed the performance of a model-based dosing calculator (Vanc App) in achieving target vancomycin concentrations at first steady-state level. Methods: This was a multicenter prospective study in four tertiary pediatric hospitals over an 18-month period. Infants aged 0-90 days with suspected Gram-positive sepsis requiring empiric vancomycin treatment were included if they did not meet any of the exclusion criteria: post-menstrual age (PMA) <25 weeks, weight <500 g, glycopeptide allergy, receiving extracorporeal membrane oxygenation, v..
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Awarded by Murdoch Children's Research Institute
Funding Acknowledgements
This work was supported by from the Royal Australasian College of Physicians Research Establishment Fellowship; The Royal Children's Hospital Foundation (Grant number 2017-877); and the Victorian Government's Operational Infrastructure Support Program supporting research at the Murdoch Children's Research Institute to AG. AG received salary support from an NHMRC Investigator Grant and a Melbourne Children's Campus Clinician-Scientist Fellowship. AW received salary support from an Australian Government and University of Melbourne Research Training Program Scholarship. The funders listed above had no role in the design and conduct of the study.