Journal article
Blood transcriptome responses in patients correlate with severity of COVID-19 disease
Y Wang, K Schughart, TM Pelaia, T Chew, K Kim, T Karvunidis, B Knippenberg, S Teoh, AL Phu, KR Short, J Iredell, I Thevarajan, J Audsley, S Macdonald, J Burcham, A McLean, B Tang, M Shojaei
Frontiers in Immunology | Published : 2023
Abstract
Background: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Infected individuals display a wide spectrum of disease severity, as defined by the World Health Organization (WHO). One of the main factors underlying this heterogeneity is the host immune response, with severe COVID-19 often associated with a hyperinflammatory state. Aim: Our current study aimed to pinpoint the specific genes and pathways underlying differences in the disease spectrum and outcomes observed, through in-depth analyses of whole blood transcriptomics in a large cohort of COVID-19 participants. Results: All WHO severity levels were wel..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
This study was funded by Snow Medical Research Foundation (BEAT COVID-19) (grant no. CT28701/G207593), the National Health and Medical Research Council (Australian Partnership for Preparedness Research on Infectious Disease Emergencies (APPRISE AppID 1116530)) and the Jack Ma Foundation. This study was also supported by intramural grants from the Helmholtz-Association (Program Infection and Immunity), and NIAID Research Grants 2-U19-AI100625-06 REVISED and 5U19A|100625-07 awarded to KS. KRS is supported by NHMRC investigator grant 2007919. The authors declare that this study received funding from A2 Milk Company. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article, or the decision to submit it for publication.