Exploring monitoring strategies for population surveillance of HPV vaccine impact using primary HPV screening

LS Velentzis; D Hawkes; M Caruana; JM Brotherton; MA Smith; L Roeske; KA Karim; SM Garland; CD Wrede; J Tan; C Wheeler; PE Castle; M Saville; K Canfell

Journal article

Exploring monitoring strategies for population surveillance of HPV vaccine impact using primary HPV screening

LS Velentzis, D Hawkes, M Caruana, JM Brotherton, MA Smith, L Roeske, KA Karim, SM Garland, CD Wrede, J Tan, C Wheeler, PE Castle, M Saville, K Canfell

Tumour Virus Research | Published : 2023

DOI: 10.1016/j.tvr.2023.200255

Abstract

Australia's cervical screening program transitioned from cytology to HPV-testing with genotyping for HPV16/18 in Dec'2017. We investigated whether program data could be used to monitor HPV vaccination program impact (commenced in 2007) on HPV16/18 prevalence and compared estimates with pre-vaccination benchmark prevalence. Pre-vaccination samples (2005–2008) (n = 1933; WHINURS), from 25 to 64-year-old women had been previously analysed with Linear Array (LA). Post-vaccination samples (2013-2014) (n = 2989; Compass pilot), from 25 to 64-year-old women, were analysed by cobas 4800 (cobas), and by LA for historical comparability. Age standardised pre-vaccination HPV16/18 prevalence was 4.85% (9..

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